Table 1.

Clinical Characteristics of Study Participants at Time of Hepatic Classification

Clinical Data Relevant for Hepatic Stratification	Mild Patients
Biochemical abnormalities without cholestasis	2
Cholestasis but no pruritus (no medications)	5
Cholestasis and pruritus responsive to medications	15
	Severe Patients
Severe cholestasis with pruritus, unresponsive to medication	1
Severe cholestasis with cirrhosis and portal hypertension	2
Biliary diversion for severe cholestasis and intractable pruritus	1
Transplantation for profound cholestasis	5
Transplantation for complications of portal hypertension	2

Cholestasis defined by

• Conjugated bilirubin > 2mg/dL, or

• GGT > 3x upper limit of normal, or