Table 3. Best overall response.
Response, n (%) | Nilotinib 400 mg bid n=18 |
Nilotinib 200 mg qd/imatinib 400 mg bid n=7 |
Nilotinib 400 mg qd/imatinib 400 mg bid n=7 |
Nilotinib 400 mg bid/imatinib 400 mg bid n=5 |
Nilotinib 400 mg bid/imatinib 400 mg qd n=16 |
---|---|---|---|---|---|
Complete response | 0 | 0 | 0 | 0 | 0 |
Partial response | 1 (6) | 0 | 0 | 0 | 1 (6) |
Stable disease | 13 (72) | 7 (100) | 5 (71) | 4 (80) | 9 (56) |
Progressive disease | 2 (11) | 0 | 1 (14) | 0 | 6 (38) |
Unknown* | 1 (6) | 0 | 0 | 0 | 0 |
N/A† | 1 (6) | 0 | 1 (14) | 1 (20) | 0 |
Progression-free survival – Kaplan-Meier estimates | |||||
Rate at 4 months, % | 59 | 83 | 43 | 50 | 56 |
Rate at 6 months, % | 47 | 17 | 29 | 50 | 56 |
Median, days | 168 | 143 | 112 | Ongoing | Ongoing |
Range | 1-393 | 56-223 | 22-336 | 1-322 | 27-180 |
Median follow-up, days | 186 | 153 | 113 | 167 | 126 |
Best response could not be classified as partial or complete response, progressive or stable disease;
Not assessed: patients had discontinued study prior to the first post-baseline tumor assessment.