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. Author manuscript; available in PMC: 2010 Apr 29.
Published in final edited form as: Chem Biol. 2008 Nov 24;15(11):1175–1186. doi: 10.1016/j.chembiol.2008.09.013

Figure 1. Organization and orientation of biosynthetic gene clusters and discrete AT didomains.

Figure 1

(A) Presumed bryostatin gene cluster from shallow-water “Candidatus Endobugula sertula”-Bugula neritina populations (Sudek et al., 2007). Enzymatic domains overexpressed in this study are zoomed. Modules putatively responsible for the portions of the bryostatin precursor, “bryostatin 0”, are noted. (B) Mupirocin (pseudomonic acid) gene cluster from Pseudomonas fluorescens NCIMB 10586 (El-Sayed et al., 2003). Scale bar = 1 kbp.