Table 5.
p values for case-control comparison on the relationships between SD and ADH1A gene using logistic regression analysis
| SD vs. controls in EAs (n=398 vs. 385) | SD vs. controls in AAs (n=160 vs. 48) | |||||||
|---|---|---|---|---|---|---|---|---|
| Variates [sample sizes (n) of SD vs. controls] | Diplotype | Haplotype | Genotype | Allele | Diplotype | Haplotype | Genotype | Allele |
| Age | 9.7E-37 | 1.5E-36 | 2.4E-35 | 2.2E-68 | 0.033 | 0.033 | 0.018 | |
| Male | 9.7E-11 | 3.1E-08 | 2.5E-06 | 2.0E-12 | 0.002 | 0.002 | 0.003 | 6.1E-05 |
| Female × TCG/TCG (or: Female × TCG × TCG) (n=5 vs. 21) | 0.050 | 0.060 | ||||||
| AGA/TCG (or: AGA × TCG) (n=8 vs. 5) | 0.029 | 0.029 | ||||||
| Sex × SNP3 | 0.031 | |||||||
| Female × SNP3ˆA/A (n=49 vs. 86) | 0.008 | |||||||
| Female × SNP3ˆA/G (n=41 vs. 107) | 0.026 | |||||||
| Female × SNP3ˆA (n=139 vs. 279) | 0.018 | |||||||
| Female × SNP2ˆC (n=36 vs. 116) | 0.020 | |||||||
| SNP1ˆA/T × SNP2ˆC/G (n=7 vs. 5) | 0.031 | |||||||
| SNP1ˆA × SNP2ˆC (n=7 vs. 5) | 0.037 | |||||||
“E-n”, scientific format of “10-n”; “×”, interaction between. The italic p values denote the sign of regression coefficient (β) is negative “-”; otherwise, positive “+”. The absolute values of all regression coefficients (βs) are less than 7. EA and AA samples have 80% power to detect allele frequency difference between cases and controls down to 0.071 and 0.162, respectively (calculated by the program PAWE).