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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Pharm Res. 2009 Aug 14;26(10):2358–2366. doi: 10.1007/s11095-009-9952-9

Fig. 2.

Fig. 2

Percentage of Gly-Sar uptake activities of the cysteine-scanning mutants of TMD10 of hPEPT1. [3H]Gly-Sar uptake (0.5 μCi/ml, 10 min at 37°C) was measured 72 h post-transfection in HEK293 cells, individually transfected with cysteine-scanning mutants of TMD10 of hPEPT1. Results represent the % Gly-Sar uptake of each mutated transporter compared with WT-hPEPT1 (n=4–7). The background uptake values of mock-transfected HEK293 cells were subtracted. *, ≤ 20% specificactivity. #, 25–35% specificactivity.