Table 5.
Properties of purinergic currents in LS and TL bladder sensory neurons from saline-treated and CYP-treated mice.
|
current type |
treatment |
ATP |
αβ-metATP |
|||||
|---|---|---|---|---|---|---|---|---|
| current density (pA/pF) |
time to peak (ms) |
desensitizin g tau (ms) |
current density (pA/pF) |
time to peak (ms) |
desensitizing tau (ms) |
|||
|
LS
|
sustained
|
saline | 15.5±5.2 | 3114±759 | n/a | n/a | n/a | n/a |
|
CYP
|
20.9±2.7 |
3615±244 |
n/a |
n/a |
n/a |
n/a |
||
|
slow
|
saline | 25.2±5.6 | 662.3± 33.4 | 2160±163 | 7.9±1.7 | 1493±144 | 5586±850 | |
|
CYP
|
31.6±4.0 |
771.4± 72.9 |
2710±402 |
10.7±1.7 |
1596±158 |
7873±1309 |
||
|
fast
|
saline | n/a | n/a | n/a | n/a | n/a | n/a | |
|
CYP
|
n/a |
n/a |
n/a |
n/a |
n/a |
n/a |
||
| TL |
sustained
|
saline | n/a | n/a | n/a | n/a | n/a | n/a |
|
CYP
|
n/a |
n/a |
n/a |
n/a |
n/a |
n/a |
||
|
slow
|
saline | 17.4±4.0 | 642.3± 69.6 | 1840±270 | 7.4±1.6 | 1683±119 | 7543±4190 | |
|
CYP
|
10.9±1.6 |
633.9± 28.1 |
2440±173 |
3.7±0.9* |
2202±199 |
4825±2499 |
||
| fast | saline | 9.1±1.7 | 261.3± 50.4 | 181.6± 7.5 | 4.5±1.1 | 268.9±56.9 | 202±4.1 | |
| CYP | 24.2± 5.0* | 242.4± 15.3 | 128.9±6.5* | 14.4±2.3* | 258.0±25.6 | 157.9± 5.0 | ||
Data are means ± SEM.
*
P < 0.05 vs. the corresponding saline-treated group.
na, not applicable