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. Author manuscript; available in PMC: 2010 Apr 29.
Published in final edited form as: Dev Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016

Figure 2. Wnt biogenesis and secretion.

Figure 2

Wnts are glycosylated and lipid modified in the ER involving Porcupine, and escorted by Wntless from the Golgi to the plasma membrane for secretion. Wntless is retrieved from endocytic vescicles back to the Golgi by the retromer complex. After secretion mature Wnts bind to HSPGs and lipoprotein particles or form multimers, which can modulate Wnt gradients and facilitate long range Wnt signaling. The number of Wnt molecules bound to the lipoprotein particle and in the multimeric form were drawn arbitrarily.