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. Author manuscript; available in PMC: 2010 Apr 29.
Published in final edited form as: Dev Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016

Figure 3. Secreted Wnt antagonists and agonists.

Figure 3

A) Antagonists. WIF and sFRP bind directly to secreted Wnts and/or Fz. DKK and SOST/WISE proteins bind LRP5/6 to prevent Fz-LRP6 complex formation. Shisa proteins trap Fz in the ER. B) Agonists. Wnts are the primary agonists and form a complex with LRP5/6 and Fz to activate signaling. Norrin acts similar to Wnt, but binds specifically to Fz4. R-spondin proteins (Rspo) act via and may bind to LRP5/6 and/or Fz receptors. In the ER, the chaperone MESD is needed for LRP5/6 maturation.