Table 1.
Detectable antiretroviral drug concentrations in bronchoalveolar lavage and plasma by drug class.
| Drug class | Drug | Lung |
Blood |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 weeks | % | 24 weeks | % | Total (%) | 4 weeks | % | 24 weeks | % | Total (%) | ||
| NRTI | 3TC | 13/22 | 43 | 14/22 | 45 | 44 | 21/21 | 83 | 20/22 | 74 | 79 |
| DDI | 0/1 | 43 | 0/1 | 45 | 44 | 0/1 | 83 | 0/1 | 74 | 79 | |
| D4T | 0/3 | 43 | 0/3 | 45 | 44 | 2/3 | 83 | 1/3 | 74 | 79 | |
| ZDV | 5/16 | 43 | 5/16 | 45 | 44 | 12/16 | 83 | 10/16 | 74 | 79 | |
| ABC | 5/12 | 43 | 5/12 | 45 | 44 | 8/10 | 83 | 6/9 | 74 | 79 | |
| FTC | 1/1 | 43 | 1/1 | 45 | 44 | 1/1 | 83 | 1/1 | 74 | 79 | |
| TDF | 0/1 | 43 | 0/1 | 45 | 44 | 1/1 | 83 | 1/1 | 74 | 79 | |
| NNRTI | EFV | 10/16 | 63 | 10/16 | 63 | 63 | 14/16 | 88 | 16/16 | 100 | 94 |
| PI | RTV | 1/5 | 54 | 1/5 | 38 | 46 | 5/5 | 100 | 5/5 | 85 | 92 |
| NFV | 4/4 | 54 | 2/4 | 38 | 46 | 4/4 | 100 | 2/4 | 85 | 92 | |
| APV | 2/3 | 54 | 2/3 | 38 | 46 | 3/3 | 100 | 3/3 | 85 | 92 | |
| LPV | 0/1 | 54 | 0/1 | 38 | 46 | 1/1 | 100 | 1/1 | 85 | 92 | |
3TC: Lamivudine; ABC: Abacavir; APV: Amprenavir; D4T: Stavudine; DDI: Didanosine; EFV: Efavirenz; FTC: Emtricitabine; LPV: Lopinavir; NFV: Nelfinavir; NNRTI: Non-nucleoside reverse transcriptase inhibitor; NRTI: Nucleoside/tide reverse transcriptase inhibitors; PI: Protease inhibitor; RTV: Ritonavir; TDF: Tenofovir; ZDV: Zidovudine.