Table 1.
Association of Subject Characteristics with Serum 8-Isoprostane and Total Oral Biofilm IgG Antibody Levels
| |
|
Median log 8-isoprostane |
Mean total biofilm IgG antibody |
|||
|---|---|---|---|---|---|---|
| Group | N | Median log 8-isoprostane (ng/ml) (interquartile range) | p Value | Mean total biofilm IgG level (ng/ml) (SE) | p Value | |
| Age | <65 yr | 3,039 | 3.66 (1.23–5.75) | 1,203.7 (26.7) | ||
| 65+ yr | 1,678 | 3.93 (2.45–6.00) | 0.0060 | 1,190.0 (35.8) | 0.76 | |
| Sex | Female | 2,643 | 3.83 (1.23–6.00) | 1,168.8 (29.1) | ||
| Male | 2,074 | 3.67 (1.23–5.75) | 0.0710 | 1,236.7 (31.5) | 0.11 | |
| Race/field center | Jackson Co | 689 | 3.14 (2.56–4.42) | 1,533.2 (55.0) | ||
| NC, blacks | 117 | 3.79 (1.23–5.38) | 1,788.9 (134.1) | |||
| NC, whites | 1,338 | 3.59 (2.62–5.67) | 1,121.8 (39.4) | |||
| Wash Co | 1,339 | 3.48 (1.23–5.59) | 1,075.7 (40.1) | |||
| Minnesota | 1,234 | 4.71 (2.78–6.00) | <0.0001 | 1,168.4 (41.9) | <0.0001 | |
| Years of education | <11 yr | 631 | 3.50 (2.15–0.30) | 1,252.2 (58.4) | ||
| 12–16 yr | 2,065 | 3.78 (1.23–6.00) | 1,185.6 (32.3) | |||
| >16 yr | 2,017 | 3.83 (1.58–6.00) | 0.0476 | 1,196.4 (32.7) | 0.60 | |
| Income ($) | <25 K | 1,112 | 3.72 (2.11–5.73) | 1,222.2 (43.6) | ||
| 25 K ≤ 50 K | 1,669 | 3.82 (1.23–5.81) | 1,211.2 (35.5) | |||
| 50 K+ | 1,759 | 3.79 (1.23–6.00) | 0.6532 | 1,153.9 (34.8) | 0.37 | |
| Smoking | Never | 2,216 | 3.74 (1.23–5.77) | 1,201.5 (31.3) | ||
| Former light | 997 | 3.99 (2.18–6.00) | 1,198.2 (46.7) | |||
| Former heavy | 787 | 3.86 (2.52–6.00) | 1,216.8 (52.1) | |||
| Current light | 110 | 3.82 (2.69–6.00) | 1,219.9 (139.5) | |||
| Current heavy | 421 | 3.57 (1.23–5.69) | 0.0461 | 1,089.4 (71.4) | 0.66 | |
| BMI | <25 | 1,256 | 3.59 (1.23–5.71) | 1,121.3 (41.4) | ||
| 25 ≤ 30 | 1,918 | 3.76 (1.72–6.00) | 1,194.4 (33.5) | |||
| 30 ≤ 35 | 1,017 | 3.88 (2.06–6.00) | 1,237.6 (45.9) | |||
| 35+ | 518 | 3.74 (2.61–5.73) | 0.1528 | 1,314.2 (64.4) | 0.06 | |
| Diabetes | No | 4,038 | 3.74 (1.23–5.98) | 1,193.7 (23.0) | ||
| Yes | 666 | 3.82 (2.54–5.86) | 0.4516 | 1,216.2 (57.6) | 0.71 | |
| Hypertension | No | 3,108 | 3.73 (1.23–5.81) | 1,158.5 (25.1) | ||
| Yes | 1,585 | 3.80 (2.27–6.00) | 0.5102 | 1,283.8 (40.1) | 0.006 | |
| LDL | Low | 2,897 | 3.78 (1.23–6.00) | 1,210.2 (26.9) | ||
| High | 1,818 | 3.72 (1.23–5.79) | 0.4087 | 1,178.8 (35.1) | 0.48 | |
| HDL | Low | 3,882 | 3.73 (1.23–5.75) | 1,243.6 (48.6) | ||
| High | 835 | 3.94 (2.57–6.00) | 0.2344 | 1,189.1 (23.8) | 0.33 | |
| Triglycerides | Low | 2,715 | 3.50 (1.23–5.41) | 1,257.3 (29.8) | ||
| High | 2,002 | 4.16 (2.66–6.00) | <0.0001 | 1,119.5 (30.0) | 0.001 | |
| Extent probing depth | Low PD | 3,521 | 3.67 (1.23–6.00) | 1,167.3 (23.7) | ||
| High PD | 1,149 | 3.88 (1.84–5.74) | 0.0382 | 1,312.4 (48.5) | 0.004 | |
| Plaque | Low PI | 3,346 | 3.81 (1.23–6.00) | 1,159.3 (24.8) | ||
| High PI | 1,118 | 3.66 (2.55–5.24) | 0.0973 | 1,377.8 (48.5) | <0.0001 | |
| Serum 8-isoprostane | 1 | NA | NA | 1,540.9 (41.9) | ||
| Quartiles | 2 | NA | NA | 1,290.9 (41.7) | ||
| 3 | NA | NA | 1,080.2 (41.9) | |||
| 4 | NA | NA | 864.3 (43.1) | <0.0001 | ||
Extent probing depth, the subject quartile rank for number of sites per subject with at least 5 mm of periodontal probing depth; low PD, extent PD <5 mm Q1–Q3; high PD, extent PD >5 mm Q4; plaque, the subject quartile rank in whole-mouth score for the Loe-Silness plaque index, PI; low plq, extent PI Q1–Q3; high Plq, extent PI Q4.
For multileveled variables, the p value reflects the Cochran Mantel-Haenszel χ2 test.