Table 5.
Adjusted Serum IgG Antibody Levels for Total and Individual Oral Biofilm Bacteria According to Quartiles of Serum 8-Isoprostane
| |
Mean (SE) serum IgG antibody levels (ng/ml) by quartiles of serum 8-isoprostane |
p Values for indicated comparison of 8-isoprostane quartiles |
|||||
|---|---|---|---|---|---|---|---|
| IgG antibody specificity (n) | 1 | 2 | 3 | 4 | Q1 vs. Q4 | Q2 vs. Q4 | Q3 vs. Q4 |
| Total biofilm IgG (4,080) | 1.584 (45) | 1,313 (44) | 1,068 (44) | 871 (46) | <0.0001 | <0.0001 | 0.002 |
| P. gingivalis (4,230) | 117.2 (7.8) | 69.0 (7.9) | 72.8 (7.8) | 56.1 (7.9) | <0.0001 | 0.24 | 0.13 |
| T. forsythensis (4,107) | 49.0 (2.3) | 48.2 (2.3) | 39.9 (2.3) | 36.3 (2.4) | 0.0002 | 0.0005 | 0.28 |
| T. denticola (4,229) | 38.2 (1.3) | 37.6 (1.3) | 30.2 (1.3) | 23.3 (1.4) | <0.0001 | <0.0001 | 0.0003 |
| Total Red biofilm IgG (4,106) | 205.9 (9.7) | 155.2 (9.7) | 144.6 (9.6) | 116.7 (10.0) | <0.0001 | 0.006 | 0.04 |
| P. intermedia (4,230) | 122.2 (4.7) | 90.2 (4.7) | 71.9 (4.6) | 59.6 (4.7) | <0.0001 | <0.0001 | 0.06 |
| P. nigrescens (4,230) | 214.1 (7.3) | 162.1 (7.3) | 120.2 (7.3) | 88.6 (7.3) | <0.0001 | <0.0001 | 0.002 |
| C. rectus (4,230) | 38.8 (2.0) | 36.9 (2.0) | 29.9 (2.0) | 27.5 (2.0) | <0.0001 | 0.001 | 0.41 |
| F. nucleatum (4,213) | 19.8 (1.1) | 22.6 (1.1) | 13.8 (1.1) | 13.3 (1.1) | <0.0001 | <0.0001 | 0.76 |
| P. micra (4,230) | 112.9 (5.3) | 120.7 (5.3) | 93.5 (5.3) | 85.1 (5.3) | 0.0003 | <0.0001 | 0.27 |
| Total Orange biofilm IgG (4,213) | 512.1 (15.5) | 432.5 (15.5) | 329.2 (15.3) | 274.1 (15.5) | <0.0001 | <0.0001 | 0.01 |
| A. actinomycetemcomitans (4,230) | 163.7 (6.6) | 174.9 (6.7) | 123.5 (6.7) | 111.4 (6.7) | <0.0001 | <0.0001 | 0.20 |
| E. corrodens (4,220) | 19.0 (1.4) | 25.9 (1.4) | 16.3 (1.4) | 15.7 (1.4) | 0.09 | <0.0001 | 0.75 |
| C. ochracea (4,230) | 40.2 (1.7) | 39.7 (1.7) | 29.9 (1.7) | 27.4 (1.7) | <0.0001 | <0.0001 | 0.30 |
| V. parvula (4,230) | 16.2 (1.0) | 14.3 (1.0) | 11.0 (1.0) | 9.7 (1.0) | <0.0001 | 0.001 | 0.34 |
| S. intermedius (4,230) | 133.8 (8.3) | 103.3 (8.3) | 106.2 (8.2) | 77.6 (8.3) | <0.0001 | 0.03 | 0.01 |
| S. oralis (4,230) | 107.8 (5.9) | 96.7 (5.9) | 54.5 (5.9) | 35.6 (6.0) | <0.0001 | <0.0001 | 0.02 |
| S. sanguis (4,230) | 94.6 (5.8) | 77.7 (5.8) | 84.8 (5.7) | 58.1 (5.8) | <0.0001 | 0.02 | 0.001 |
| S. noxia (4,230) | 168.8 (10.3) | 87.2 (10.3) | 65.7 (10.2) | 46.3 (10.4) | <0.0001 | 0.006 | 0.18 |
| A. viscosus (4,221) | 100.9 (6.8) | 98.0 (6.8) | 88.6 (6.8) | 76.4 (6.8) | 0.01 | 0.03 | 0.21 |
| Other biofilm IgG (4,211) | 748.8 (25.0) | 619.5 (25.0) | 491.9 (24.8) | 381.8 (25.1) | <0.0001 | <0.0001 | 0.002 |
Adjusted for race/center, age, gender, BMI, smoking, education, income, diabetes, hypertension, HDL, LDL, triglycerides, pocket depth, and oral plaque level.