Table III.

Chelator-induced uranium excretion in non-bile duct-cannulated (intact) rats: Multiple dose chelator administration regimen ^a.

Compound/Structure	n	Day	Urine U Excretionb (µg kg−1)	Fecal U Excretionb (µg kg−1)	Total U Excretion (µg kg−1)	% Administered Dose Excreted	Renal Conc. (µg g−1)	Reduction (%)
Control: Uranyl Acetate 1 mg U kg−1 SC		Day 1	295 ± 125	33 ± 14	328 ± 122	32.8
	4	Day 2	58 ± 8	32 ± 10	90 ± 3	9.0
		Day 3	34 ± 7	15 ± 5	49 ± 11	4.9
		Day 4	17 ± 9	30 ± 16	47 ± 23	4.7	31 ± 6	-
		Day 1	380 ± 55	30 ± 19	410 ± 56	41.0
	5	Day 2	43 ± 11	13 ± 9	56 ± 16c	5.6
		Day 3	29 ± 6	13 ± 5	42 ± 5	4.2
		Day 4	14 ± 3	9 ± 5	23 ± 3	2.3	19 ± 2c	39
		Day 1	205 ± 27	478 ± 181	683 ± 161d	68.3
	4	Day 2	39 ± 5	116 ± 46	155 ± 48d	15.5
		Day 3	23 ± 4	33 ± 4	56 ± 7	5.6
		Day 4	11 ± 1	25 ± 2	36 ± 1	3.6	12 ± 2c	62

Data are presented as the mean ± the standard error of the mean; n, number of animals; p-values were generated via a one-tailed student’s t-test.

^aNon-bile duct-cannulated (intact) rats were given uranium s.c. (left flank) at a dose of 1 mg U kg⁻¹. The animals were given the chelators s.c. (right flank) at a dose of 300 µmol kg⁻¹ immediately thereafter. Additional s.c. doses of DTPA or 9 were given at 24-h intervals for three more days (4 doses total).

^bUrine and feces were collected at 24-h intervals.

^cMean is significantly less than control.

^dMean is significantly greater than control.