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. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Eur J Endocrinol. 2010 Jan 20;162(4):787–794. doi: 10.1530/EJE-09-1085

Illustrative pulsatile T-concentration profiles in a 28-year-old subject administered ketoconazole and glucocorticoid replacement to deplete endogenous T followed by 7 consecutive 30-min i.v. pulses of 0.46, 1.4 or 4.2 µmol T (top-to-bottom), one every 90 min superimposed upon a basal T infusion, following a 3-hr baseline interval. Panel A. Profiles of three T moieties (total, bioavailable and free) estimated in each 10-min serum sample from mean SHBG and albumin concentrations measured every hr (Methods). Panel B. Profiles of SHBG- and albumin-bound T in the same subject.

Illustrative pulsatile T-concentration profiles in a 28-year-old subject administered ketoconazole and glucocorticoid replacement to deplete endogenous T followed by 7 consecutive 30-min i.v. pulses of 0.46, 1.4 or 4.2 µmol T (top-to-bottom), one every 90 min superimposed upon a basal T infusion, following a 3-hr baseline interval. Panel A. Profiles of three T moieties (total, bioavailable and free) estimated in each 10-min serum sample from mean SHBG and albumin concentrations measured every hr (Methods). Panel B. Profiles of SHBG- and albumin-bound T in the same subject.

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