Fig. 1. PNS mice are hyperphagic on a chow diet.
(A, B) PNS mice on a chow diet show significantly greater caloric intake than control mice over 4 months (*, p < 0.05, main effect of PNS treatment). Mice consume significantly fewer total calories while on the high fat diet (45% fat) compared to chow intake over 4 months (#, p < 0.001, main effect of diet). (C) PNS males on a chow diet show a significantly reduced caloric efficiency compared to control males (*, p < 0.05). (C) Male and (D) female mice on a high fat diet show greater caloric efficiency compared to chow diet (#, p < 0.0001, main effect of diet).