. Author manuscript; available in PMC: 2010 Apr 29.

Published in final edited form as: Physiol Behav. 2009 Apr 23;98(1-2):94–102. doi: 10.1016/j.physbeh.2009.04.015

Table 1.

Monthly fasting glucose levels in mice

			MONTH
			ONE	TWO	THREE	FOUR
*Male*	Chow	Ctrl	104.6 ± 7.5	105.3 ± 7.7	82.3 ± 3.7	106.2 ± 8.9
	Chow	PNS	114.7 ± 8.6	126.7 ± 2.9	86.6 ± 6.2	100.3 ± 6.2
	High Fat	Ctrl	130.6 ± 6.8	120.4 ± 6.0	133.5 ± 6.3^*	132.6 ± 5.3^*
	High Fat	PNS	107.8 ± 6.3	118.6 ± 5.6	133.4 ± 9.7^*	137.9 ± 7.8^*

*Female*	Chow	Ctrl	101.6 ± 6.6	106.1 ± 8.5	86.6 ± 6.6	98.3 ± 5.3
	Chow	PNS	93.1 ± 7.5	90.0 ± 7.0	81.1 ± 5.5	101.0 ± 11.6
	High Fat	Ctrl	108.9 ± 6.8^*	147.7 ± 9.8^*	111.1 ± 7.5^*	119.6 ± 5.4
	High Fat	PNS	116.8 ± 6.0^*	124.1 ± 4.4^*	98.5 ± 6.3^*	103.1 ± 6.2

All results are shown as mg/dl.

Main effect of high fat diet (Males: p < 0.0001; Females: p < 0.01).

Male mice exposed to a high fat diet for three and four months show significantly greater fasting glucose levels (*, p < 0.0001). No effect of PNS treatment was detected for male mice on either chow or high fat diet. Female mice show an early impact of high fat diet on fasting glucose levels with significantly greater levels at one, two and three months (*, p < 0.01). These differences were not detected at four months of diet exposure. No effect of PNS treatment was observed.