Fig. 3. Elevated expression of miR-21 promotes enhanced tumor growth and castration-resistance in vivo.
LNCaP miR-21 (black square) or a control vector (white circle) subcutaneous xenograft growth before and after castration. Castration was performed at ~ 375 mm3 tumor volume for each group. Tumor growth is normalized to the time of castration (day 0). Inset: Time course of tumor growth from the time of injection. Castration indicated by arrows. Mean ± S.E of at least 10 independent values. *P<0.05 (t-student test).