Table 1. Neutralizing antibody response against FMDV C-S8c1, in mice, after vaccination with C-S8p260.
C-S8p260a | Neutralization titer (PRN70)b | |
107 PFUs | 30 days PIc | 3 days PCd |
Mouse # | ||
1 | 2.0 | 1.8 |
2 | 2.0 | 2.0 |
3 | 2.4 | 2.2 |
4 | 2.1 | 1.9 |
5 | 1.3 | 1.5 |
6 | 1.7 | 1.8 |
7 | 0.4 | 1.9 |
8 | 1.7 | 1.8 |
9 | 2.7 | 2.4 |
10 | 1.9 | 1.9 |
103 PFUs | ||
Mouse # | ||
20 | 2.0 | 1.9 |
21 | 2.1 | 1.8 |
22 | <0 | 1.8 |
23 | 1.7 | 1.8 |
24 | 1.4 | 2.4 |
25 | 1.6 | 1.8 |
26 | 1.4 | 1.8 |
27 | 0.6 | 1.1 |
28 | 1.4 | 1.5 |
29 | 1.7 | 1.8 |
Mice were vaccinated with 107 PFUs or 103 PFUs of C-S8p260, indicated for each group.
Neutralization titers are expressed as PRN70 (plaque-reduction neutralization titer 70): the reciprocal of the dilution of serum that causes neutralization of 70% of PFU.
30 days post-immunization.
3 days post-challenge with 104 PFUs of C-S8c1.