Table 3. Neutralizing antibody response to FMDV C-S8c1 in sera of pigs vaccinated with C-S8p260.
Animals | Virus neutralization titers (VNT)a at the indicated day after immunization | ||||
0 | 15 | 30 | 32 (D2 pc)b | 39 (D7 pc)c | |
Group #1 | |||||
1 | <0 | 1.2 | 1.8 | 2.5 | 3.7 |
2 | <0 | 1.3 | 1.5 | 3.0 | 3.6 |
3 | <0 | 2.2 | 3.4 | 3.4 | 3.5 |
4 | <0 | 1.9 | 2.5 | 2.5 | 3.3 |
5 | <0 | 1.5 | 2.3 | 2.3 | 3.4 |
6 | <0 | 1.3 | 2.8 | 2.7 | 2.7 |
Group #2 | |||||
7 | <0 | 2.4 | 2.3 | 2.5 | 2.8 |
8 | <0 | <0 | 1.8 | 2.3 | 3.0 |
9 | <0 | <0 | 2.2 | 2.5 | 3.0 |
Group #3 | |||||
10 | <0 | <0 | 1.8 | 1.8 | 2.7 |
11 | <0 | <0 | 1.4 | 1.3 | 3.0 |
Group #4 | |||||
12 | <0 | <0 | <0 | 1.7 | 1.7 |
13 | <0 | 0.4 | 2.0 | 2.0 | 3.1 |
14 | <0 | 2.5 | 2.5 | 2.6 | 3.2 |
Group #5 | |||||
15 | <0 | <0 | <0 | <0 | 2.3d |
16 | <0 | <0 | <0 | <0 | 3.1d |
17 | <0 | <0 | <0 | <0 | 2.2d |
VNT, virus neutralization titer (log10 of the reciprocal of the last dilution able to neutralize 70% of 100 PFUs of FMDV C-S8c1).
Day 2 post-challenge with 105 PFUs of FMDV C-S8c1.
Day 7 post-challenge with 105 PFUs of FMDV C-S8c1.
For control animals, VNT was obtained at day 12 pc.