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. 2010 Apr 29;6(4):e1000764. doi: 10.1371/journal.pcbi.1000764

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic diagram of the yeast cell polarization signal transduction pathway. (B) The active state (upper black) and the inactive state (lower red). The upper black curve is the output (concentration of Cdc42a) response to the constant high pheromone concentration of [L]nM, and the lower red curve is the output response to the low pheromone concentration of [L]nM. (C) A noisy input signal with low amplitude. (D) The output response to (C). (E) A noisy input signal with large amplitude. (F) The output response to (E). (G) The noise amplification rate versus the signed activation time. Ten parameters are varied systematically in -fold ranges based on their original values given in (D). Each variation corresponds to one curve on the plot. The ten parameters are (red), (black), (pink), (magenta), (yellow), (orange), (cyan), (green), (blue), (brown). The leftmost point of the curve is not shown in this picture, as it changes the scale of the picture. Please see Figure S7 for the full plot. Parameter values are mostly taken from [37], except and , because of the loss of the spatial effect. The initial conditions are , , where .

Inline graphic — (A) Schematic diagram of the yeast cell polarization signal transduction pathway. (B) The active state (upper black) and the inactive state (lower red). The upper black curve is the output (concentration of Cdc42a) response to the constant high pheromone concentration of [L]nM, and the lower red curve is the output response to the low pheromone concentration of [L]nM. (C) A noisy input signal with low amplitude. (D) The output response to (C). (E) A noisy input signal with large amplitude. (F) The output response to (E). (G) The noise amplification rate versus the signed activation time. Ten parameters are varied systematically in -fold ranges based on their original values given in (D). Each variation corresponds to one curve on the plot. The ten parameters are (red), (black), (pink), (magenta), (yellow), (orange), (cyan), (green), (blue), (brown). The leftmost point of the curve is not shown in this picture, as it changes the scale of the picture. Please see Figure S7 for the full plot. Parameter values are mostly taken from [37], except and , because of the loss of the spatial effect. The initial conditions are , , where .