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. 2010 Apr 29;6(4):e1000891. doi: 10.1371/journal.ppat.1000891

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Inhibition of HIV p24 production by infected autologous CD4⁺ T cells was monitored after incubation with variously stimulated CD8⁺ T cells. Mean p24 values of triplicates (+SD) from one donor on day 11 post addition of HIV-specific CD8⁺ T cells to NL4-3-incubated CD4⁺ T cells are shown. Inhibition by HIV-C-DC-primed CD8⁺ T cells was significantly greater than CD8⁺ T cells primed with non-opsonized HIV (p = 0.0085). Similar results were obtained with cells isolated from 7 different donors using R5-, X4- and R5X4-tropic viral isolates, BaL, 92BR030, 92UG037, NL4-3, 93BR020 (data not shown). A summary of all data in one graph was not feasible due to donor- and virus strain-dependent differences in the infection efficiency, therefore p24 values of one representative donor is shown in this figure.