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. 2010 Apr 29;6(4):e1000892. doi: 10.1371/journal.ppat.1000892

Figure 4. TLR ligand-induced maturation of mononuclear cells facilitates S. mansoni development.

Figure 4

(A) Relative numbers of monocytes in the spleens of LPS-treated and control (PBS-treated) RAG-1-/- mice. (B) Representative micrographs of parasites isolated from RAG-2-/- mice at six weeks post infection after weekly treatment with 2 µg or LPS. Control animals received carrier (PBS) alone. (C) Length of male worms and (D) egg production by schistosome pairs from RAG-2-/- BALB/c mice at six weeks post infection after weekly treatment with 2 µg or LPS. Control animals received carrier (PBS) alone. Mean values are represented by horizontal bars. (E) Length of male worms and (F) egg production by schistosome pairs from RAG-1-/- C57BL/6 mice at six weeks post infection after weekly treatment with 2 µg or 20 µg LPS. Control animals received carrier (PBS) alone. Mean values are represented by horizontal bars. Groups of 4–5 mice were used for each experimental condition. Data are representative of at least five independent experiments.