Richard Siegel’s interest in immunology, autoimmunity, and apoptosis began as an MD/PhD student at the University of Pennsylvania School of Medicine, from which he graduated in 1993. He trained in Internal Medicine and Rheumatology at Hospital of the University of Pennsylvania, and then moved to the NIH to do postdoctoral training 1996, where he worked in Michael Lenardo’s laboratory in NIAID studying the molecular basis of autoimmunity in the Autoimmune Lymphoproliferative Syndrome (ALPS). In 2001, Dr. Siegel moved to the National Institute of Arthritis, Musculoskeletal Diseases and Skin (NIAMS) at the NIH as an Investigator, where he also attends on the Rheumatology service at the NIH Clinical Center. He is presently Senior Investigator and Acting Chief of the Autoimmunity Branch in NIAMS, where he directs the Immunoregulation Section. The Siegel lab seeks to understand how alterations in regulatory signaling pathways in immune cells lead to abnormal immune responses, chronic inflammation, and autoimmune diseases. The lab has focused principally on the biology of TNF-family cytokines in normal and pathological immune responses. More about the lab can be found at www.niams.nih.gov/Research/Ongoing_Research/Branch_Lab/Autoimmunity/irg.asp. E-mail siegelr@mail.nih.gov; fax 301-451-5394.