Table 3.

Effect of Plantago major L. on histopathological changes in the liver of the study groups*

Groups	Microscopic observation
	Ballooning degeneration and steatosis	Apoptosis and/or necrosis of hepatocytes	Bridging necrosis
ISS	0	0	0
CCl4	+++	+++	+++
Silibinin	+	+	+
PM 10 mg/kg	+++	+++	+++
PM 20 mg/kg	+++	+++	+++
PM 25 mg/kg	++	+	+

0: absent

⁺: mild

⁺⁺: moderate

⁺⁺⁺: severe.