Table 1.

Respiratory burst activity in various groups on acute and chronic treatment with cocaine ± drugs

Acute model	Chronic model
Groups	Respiratory burst (OD540/106 cells/ 30 min)		Respiratory burst (OD540/106 cells/ 30 min)
	Unstimulated Mφ	PMA Stimulated Mφ	Unstimulated Mφ	PMA Stimulated Mφ
Control	0.07 ± 0.02	0.45 ± 0.05	0.07 ± 0.02	0.57 ± 0.06
Cocaine	0.12 ± 0.02a	0.44 ± 0.06	0.20 ± 0.03d	0.28 ± 0.11f
Cocaine + O. sanctum	0.08 ± 0.01b	0.30 ± 0.03c	0.09 ± 0.04e	0.49 ± 0.14g
Cocaine + ascorbic acid	0.07 ± 0.02b	0.26 ± 0.03c	0.11 ± 0.02e	0.31 ± 0.04
Cocaine + verapamil	0.08 ± 0.01b	0.28 ± 0.08c	0.07 ± 0.02e	0.39 ± 0.05

Values are Mean ± SEM. n = 6 in each group. P values; acute model- a < 0.001 vs. control, b < 0.01 cocaine In unstimulated respiratory burst, c < 0.001 vs. control In PMA stimulated respiratory burst and chronic model - d < 0.001 vs. control, e < 0.001 vs. cocaine in unstimulated respiratory burst, f < 0.001 vs. control, g < 0.001 vs. cocaine in PMA stimulated respiratory burst. One-way ANOVA followed by Tukey's test. Mφ- macrophage. PMA- Phorbol Myristate Acetate