Table 2.
Superoxide production in various groups on acute and chronic treatment with cocaine ± drugs
| Acute model | Chronic model | |||
|---|---|---|---|---|
| Groups | Superoxide production (nM/106 cells/ 30 min) | Superoxide production (nM/106 cells/ 30 min) | ||
| Unstimulated Mφ | PMA Stimulated Mφ | Unstimulated Mφ | PMA Stimulated Mφ | |
| Control | 0.76 ± 0.23 | 3.39 ± 0.96 | 0.64 ± 0.07 | 4.47 ± 0.64 |
| Cocaine | 1.62 ± 0.32a | 4.21 ± 0.59 | 1.77 ± 0.55 | 1.80 ± 0.50d |
| Cocaine + O. sanctum | 1.03 ± 0.43 | 3.85 ± 0.62 | 0.80 ± 0.12c | 4.12 ± 0.57e |
| Cocaine + ascorbic acid | 0.88 ± 0.24b | 3.96 ± 0.40 | 0.92 ± 0.34c | 3.74 ± 0.41e |
| Cocaine + verapamil | 1.09 ± 0.32 | 3.81 ± 0.89 | 0.94 ± 0.16c | 4.00 ± 0.44e |
Values are Mean ± SEM. n = 6 in each group. P values; acute model- a < 0.001 vs. control, b < 0.01 cocaine In unstimulated Superoxide production, and chronic model- c < 0.001 vs. cocaine in Unstimulated Superoxide production, d < 0.001 vs. control, e < 0.001 vs. cocaine in PMA stimulated Superoxide production. One-way ANOVA followed by Tukey's test. Mφ- macrophage. PMA- Phorbol Myristate Acetate