Table 4.
Estimation of TNF-α level in various arouos on acute and chronic treatment with cocaine ± druas
| Acute model | Chronic model | |||
|---|---|---|---|---|
| Groups | TNF- α level (pg/ml) | TNF- α level (pg/ml) | ||
| Supernatant | Serum | Supernatant | Serum | |
| Control | 35.40 ± 3.35 | 24.62 ± 2.33 | 35.29 ± 2.82 | 25.32 ± 2.09 |
| Cocaine | 44.73 ± 2.24a | 27.88 ± 2.66 | 50.56 ± 3.69c | 32.15 ± 2.81 |
| Cocaine + O.sanctum | 40.35 ± 2.54 | 25.42 ± 1.88 | 26.24 ± 1.73 | 21.25 ± 2.49 |
| Cocaine + ascorbic acid | 35.45 ± 2.46b | 28.57 ± 2.07 | 29.31 ± 1.38d | 19.90 ± 2.64 |
| Cocaine + verapamil | 35.58 ± 2.22b | 27.83 ± 2.08 | 29.93 ± 3.20d | 17.34 ± 1.90 |
Values are Mean ± SEM. n = 6 in each group. P values; acute model- a < 0.001 vs. control, b < 0.01 vs. cocaine, and chronic model- c < 0.001 vs. control, d < 0.001 vs. cocaine. One-way ANOVA followed by Tukey's test.