Table 5.
Oxidative status of various groups on acute and chronic treatment with cocaine ± drugs
| Acute model | Chronic model | |||
|---|---|---|---|---|
| Groups | MDA levels (nM/ml) | Superoxide dismutase activity (U/gmHb) | MDA levels (nM/ml) | Superoxide dismutase activity (U/gmHb) |
| Control | 3.43 ± 0.46 | 1414 ± 118 | 3.47 ± 0.60 | 1480 ± 131 |
| Cocaine | 4.01 ± 0.52 | 1471 ± 148 | 6.70 ± 0.78b | 1163 ± 125d |
| Cocaine + O.sanctum | 4.09 ± 0.30 | 1221 ± 141 | 4.11 ± 0.59c | 2249 ± 323e |
| Cocaine + ascorbic acid | 3.57 ± 0.56a | 1208 ± 122 | 3.69 ± 0.54c | 1589 ± 209e |
| Cocaine+verapamil | 3.40 ± 0.59a | 1297 ± 102 | 3.48 ± 0.31c | 1748 ± 279e |
Values are Mean ± SEM. n = 6 in each group. P values; acute model- a < 0.001 vs. cocaine, and chronic model- b < 0.01 vs. control, c < 0.001 vs. cocaine in MDA levels, d < 0.001 vs. control, e < 0.001 vs. control in superoxide dismutase activity. One-way ANOVA followed by Tukey's test. MDA- serum malondialdehyde.