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Amino acid sequence of human ORAI1. Residues E106, D110, D112, D114, and E190, that when mutated affect channel properties, are shown in blue. Residues R91, A103, and L194, that when mutated to W, E, and P, respectively, are associated with human immunodeficiency, are shown in red (20, 93). Residues 65 and 74 are indicated; truncated ORAI1 proteins that begin at either residue are able to assemble and function as CRAC channels (33, 36, 150).
