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Ramachandran free energy differences of (a)-(f) of select solvation methods from explicit SPC/E water for alanine-dipeptide. (g) Difference of 3D-RISM-KH with a residual tolerance of 10−5 and 3D-RISM-KH with a FCE RESPA MTS time step of Δt=20 fs. Energy units are in kcal/mol.