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. Author manuscript; available in PMC: 2010 Apr 30.
Published in final edited form as: Proc SPIE Int Soc Opt Eng. 2009;7321:732105. doi: 10.1117/12.820419

Fig. 4.

Fig. 4

The new cocaine aptamer constructs – concaptamer and pseudosandwich – exhibit excellent cocaine response. (Top and bottom left) The absolute SWV peak currents for both the concaptamer and pseudosandwich are lower in magnitude that the original E-AB sensor as a result of the slower collision dynamics of the longer strands [19,20]. However, the presence of cocaine is signaled by an increase in peak currents leading to improved signal gain over the original aptamer sensor. (Top and bottom right) The concaptamer and pseudosandwich E-AB sensors exhibit cocaine binding affinities of 230 ± 40 μM and 165 ± 42 μM respectively with sensors fabricated using 0.025 μM DNA.