TABLE 1.
Clinicopathologic characteristic of patients with periampullary cancers undergoing pancreaticoduodenectomy, by tumor type
| Cholangiocarcinoma | Ampullary cancer | Pancreatic cancer | P | |
|---|---|---|---|---|
| Number of patients | 18 | 79 | 249 | |
| Male | 13 (55%) | 47 (59%) | 151 (61%) | 0.893 |
| Mean age (SD), years | 66.1 (10.7) | 63.4 (11.2) | 64.4 (10.7) | 0.6 |
| Comorbidities | 9 (50%) | 44 (55%) | 163 (66%) | 0.1 |
| Presentation | ||||
| Jaundice | 15 (83%) | 53 (67%) | 182 (73%) | 0.283 |
| Abdominal pain | 5 (28%) | 15 (6%) | 90 (36%) | 0.014 |
| Preoperative stent | 4 (22%) | 30 (38%) | 103 (41%) | 0.6 |
| Mean (SD) preoperative CA19-9, U/mL | 134 (282) | 1,867 (7,158) | 1,083 (2,807) | 0.37 |
| Elevated CA19-9 (>35 U/mL) | 4 (23%) | 54 (68%) | 214 (86%) | <0.001 |
| Pylorus preservation | 5 (28%) | 32 (41%) | 63 (25%) | 0.029 |
| Size, mean (SD), cm | 2.2 (1.0) | 2.4 (1.6) | 3.4 (1.4) | <0.001 |
| Poor differentiation | 5 (28%) | 20 (25%) | 85 (34%) | 0.3 |
| Positive nodes | 6 (33%) | 35 (45%) | 161 (68%) | <0.001 |
| Neural invasion | 6 (33%) | 16 (20%) | 206 (74%) | <0.001 |
| Lymphovascular invasion | 2 (11%) | 24 (30%) | 117 (48%) | 0.01 |
| Negative margins | 15 (83%) | 76 (96%) | 205 (82%) | 0.007 |
| Complications | 3 (17%) | 40 (50%) | 102 (41%) | 0.027 |
| Perioperative mortality | 1 (5.5%) | 2 (2.5%) | 12 (4.8%) | 0.2 |