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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nanomedicine (Lond). 2010 Feb;5(2):269–285. doi: 10.2217/nnm.10.1

Figure 2. Mechanism for siRNA-based gene therapy of HIV/AIDS.

Figure 2

The siRNA acts by degrading mRNA in at least two major ways: (A) Inhibit entry and fusion by interfering with production of receptors or co-receptors and (B) interfere with translation and transcription of viral genes preventing production of proteins and genomic RNA. (The viral entry and replication stages shown here are also the targets for the antiretroviral drugs discussed above [29]).