Table 4.

Peak areas and S/N ratios from the CCD experiment for the optimization of sheath liquid parameters and spray chamber parameters.

Sheath liquid parameters
Exp. #	Experimental parameters			Experimental response
	MeOH%	pH	[NH4OAc]	Average peak area		(S/N)avg
	(v/v)		(mM)	BNP	BOH	BNP	BOH
1	20	8.50	40.0	14427	99432	21	113
2	50	5.15	22.5	49152	290824	206	960
3	50	7.25	22.5	40602	241814	115	559
4	50	7.25	51.9	29718	223362	115	706
5	50	7.25	22.5	39097	232124	99	492
6	20	6.00	40.0	9252	67256	16	93
7	50	7.25	22.5	45068	298748	106	562
8	100	7.25	22.5	15281	222053	23	273
9	0	7.25	22.5	3478	10883	7	18
10	20	6.00	5.0	63326	177618	90	196
11	50	7.25	22.5	42950	275642	100	506
12	50	7.25	22.5	48909	272059	133	594
13	50	9.35	22.5	49445	296241	132	623
14	50	7.25	0.0	208453	242844	125	127
15	80	8.50	40.0	37082	307778	165	1092
16	20	8.50	5.0	59459	159065	93	211
17	80	6.00	5.0	11830	492208	178	596
18	50	7.25	22.5	52173	302398	156	678
19	80	6.00	40.0	38757	327795	139	913
20	80	8.50	5.0	139984	540163	247	749

Spray chamber parameters
Exp. #	Experimental parameters		Experimental response
	DGF (L/min)	DGT (°C)	Average peak area		(S/N)avg
			BNP	BOH	BNP	BOH
1	6.4	200	111512	400420	30	95
2	5.0	200	133235	427354	30	83
3	3.6	200	87505	293752	27	84
4	5.0	200	109555	366425	25	71
5	5.0	200	71654	269713	25	83
6	5.0	200	76124	276415	22	70
7	5.0	129	71120	226286	27	74
8	6.0	150	73594	246687	27	72
9	4.0	150	76428	325822	26	96
10	5.0	200	83234	276337	24	70
11	5.0	271	105381	377627	23	70
12	6.0	250	78936	283556	29	83
13	4.0	250	103499	388948	23	71