Table 3.

Activities of besifloxacin and other antibiotics against anaerobic bacteria²¹

Species (no of test isolates) and test drug	MICa (μg/mL)
	Range	50%	90%
Clostridium perfringens (n = 21)
Besifloxacin	0.12–0.25	0.25	0.25
Moxifloxacin	0.25–0.5	0.5	0.5
Gatifloxacin	0.5–1	1	1
Clindamycin	0.06–4	2	4
Metronidazole	1–4	2	4
Fusobacterium species (n = 21)
Besifloxacin	0.12–8	0.25	1
Moxifloxacin	0.25 to >16	1	2
Gatifloxacin	0.5 to >16	1	4
Clindamycin	0.06–8	0.06	2
Metronidazole	≤0.12–2	0.25	1
Peptostreptococcus species (n = 52)
Besifloxacin	0.06–2	0.25	0.5
Moxifloxacin	0.25–4	0.25	0.5
Ciprofloxacin	0.5 to >8	2	4
Clindamycin	0.06 to >8	0.25	>8
Metronidazole	≤0.03 to >16	0.5	1
Propionibacterium acnes (n = 21)
Besifloxacin	0.12–0.25	0.25	0.25
Moxifloxacin	0.25–0.25	0.25	0.25
Gatifloxacin	0.25–0.5	0.25	0.5
Clindamycin	≤0.03–2	0.06	0.12
Metronidazole	>16 to >16	>16	>16

^aMinimum inhibitory concentration.