Table 4.

Mean and median fluoroquinolone concentrations in conjunctival tissue (mITT population)

		Besifloxacin 0.6% (μg/g) N = 36	Moxifloxacin 0.5% (μg/g) N = 36	Gatifloxacin 0.3% (μg/g) N = 36
15 minutes	Mean (SD)	2.30 (1.42)	10.7 (5.89)	4.03 (3.84)
	Median	1.65	9.23	3.04
30 minutes	Mean (SD)	2.29 (1.30)	4.04 (4.16)	2.76 (0.737)
	Median	1.75	2.80	2.61
2 hours	Mean (SD)	0.418 (0.281)	0.845 (0.440)	0.448 (0.284)
	Median	0.442	0.917	0.444
6 hours	Mean (SD)	0.324 (0.355)	0.228 (0.162)	0.162 (0.205)
	Median	0.161	0.184	0.0936
12 hours	Mean (SD)	0.122 (0.196)	0.146 (0.123)	0.0586 (0.0675)
	Median	0.0447	0.134	0.0311
24 hours	Mean (SD)	0.0338 (0.0262)	0.0248 (0.0309)	0.0186 (0.0133)
	Median	0.0309	0.00895	0.0127

Notes: Biopsies were performed at 15 ± 1 minute, 30 ± 1 minute, 2 hours ± 5 minutes, 6 hours ± 15 minutes, 12 hours ± 15 minutes, and 24 hours ± 15 minutes. Biopsy samples containing a concentration of drug below the lower limit of quantitation (LLOQ = 17.9 ng/g) were assigned a value equal to one-half the LLOQ (8.95 ng/g).

Abbreviations: mITT, modified intent-to-treat population (N = 108); SD, standard deviation.