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. Author manuscript; available in PMC: 2010 Apr 30.
Published in final edited form as: Circ Res. 2007 Nov 8;102(2):201–208. doi: 10.1161/CIRCRESAHA.107.158626

Figure 5.

Figure 5

Ang II causes telomere attrition in hVSMCs. A, Dose-response of Ang II on telomere length in hVSMCs, for 24 hours. Mean percentage telomere changes per PD with SEM shown; n=5. (P<0.001 for all doses compared with control). B, Ang II treatment accelerates hVSMC telomere attrition via the AT1 receptor. Telomere length was measured in hVSMCs grown continuously in media supplemented daily for 7 days with Ang II (10−6 mol/L)±E3174 (10−5 mol/L). *P<0.05 vs all other treatments; n=9; n=3 for E3174 alone.