Table 1.
Baseline demographics and clinical characteristics by uncarboxylated matrix Gla protein (ucMGP) tertiles
| Characteristics | Tertile 1 <2,757 (n = 280) |
ucMGP, nM Tertile 2 2,757-3,648 (n = 280) |
Tertile 3 >3,648 (n = 279) |
P value |
|---|---|---|---|---|
| Demographics | ||||
| Age, y | 71 (63-79) | 68 (60-76) | 64 (56-71) | <0.001 |
| Male Sex, No. (%) | 237 (85) | 227 (81) | 218 (78) | 0.14 |
| Race | 0.54 | |||
| Caucasian, No. (%) | 178 (64) | 168 (60) | 158 (57) | |
| African-American, No. (%) | 42 (15) | 47 (17) | 47 (17) | |
| Other, No. (%) | 60 (21) | 64 (23) | 74 (27) | |
| Regular Alcohol Use, No. (%) | 70 (25) | 76 (27) | 94 (34) | 0.07 |
| Current smoking, No. (%) | 44 (16) | 61 (22) | 66 (24) | 0.06 |
| Body mass index, kg/m2 * | 27 (24-30) | 27 (25-31) | 29 (26-33) | <0.001 |
| Medical History | ||||
| Hypertension, No. (%) | 191 (69) | 211 (75) | 201 (72) | 0.24 |
| Diabetes, No. (%) | 56 (20) | 75 (27) | 90 (32) | 0.01 |
| Myocardial Infarction, No. (%) | 157 (56) | 143 (51) | 147 (53) | 0.46 |
| Angioplasty, No. (%) | 105 (38) | 107 (38) | 116 (42) | 0.59 |
| Coronary Bypass, No. (%) | 106 (38) | 108 (39) | 91 (33) | 0.31 |
| Heart failure, No. (%) | 44 (16) | 54 (19) | 52 (19) | 0.51 |
| Measurements | ||||
| SBP, mmHg | 131 (22) | 135 (22) | 133 (20) | 0.09 |
| DBP, mmHg | 72 (11) | 75 (12) | 76 (11) | <0.001 |
| eGFR, ml/min† | 64 (22) | 71 (21) | 77 (20) | <0.001 |
| Cholesterol, mg/dL* | 164 (143-186) | 169 (145-191) | 182 (157-210) | <0.001 |
| HDL, mg/dL | 47 (14) | 45 (14) | 46 (14) | 0.30 |
| CRP, mcg/dL* | 2.27 (0.98-4.89) | 2.21 (0.87-5.43) | 2.32 (1.01-4.97) | 0.96 |
| Albumin, g/dL* | 3.8 (3.6-4.0) | 3.9 (3.7-4.1) | 4.0 (3.8-4.2) | <0.001 |
| Fibrinogen, mg/dL* | 382 (332-443) | 389 (336-453) | 379(332-443) | 0.78 |
| Calcium, mg/dL | 9.4 (0.5) | 9.5 (0.5) | 9.6 (0.5) | <0.001 |
| Phosphorus, mg/dL* | 3.6 (3.2-3.9) | 3.7 (3.3-4.0) | 3.7 (3.3-4.1) | 0.02 |
| Fetuin-A, g/L * | 0.60 (0.52-0.68) | 0.64 (0.56-0.73) | 0.68 (0.60-0.79) | <0.001 |
Abbreviations: CRP, C-reactive protein; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate, HDL, high density lipoprotein cholesterol; SBP, systolic blood pressure
Data are presented as mean (SD) unless otherwise specified
*
Median (intra-quartile range)
†
eGFR = 76.7 × (cystatin-C−119)