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. Author manuscript; available in PMC: 2011 May 7.
Published in final edited form as: Org Lett. 2010 May 7;12(9):2166–2169. doi: 10.1021/ol100745d

Table 3.

Toward synthesis of 1,5-disubstituted triazoles.a

graphic file with name nihms195523u4.jpg
no. substrate catalyst 4 5
1 graphic file with name nihms195523t33.jpg RuCpCl(PPh3)2 - -
2 graphic file with name nihms195523t34.jpg RuCp*Cl(PPh3)2 - -
3 graphic file with name nihms195523t35.jpg (CuOTf)2C6H6 81% -
4 graphic file with name nihms195523t36.jpg RuCp*Cl(PPh3)2 23% 36%b
5 graphic file with name nihms195523t37.jpg (CuOTf)2C6H6 91% -
6 graphic file with name nihms195523t38.jpg RuCp*Cl(PPh3)2 3% 56%
7 graphic file with name nihms195523t39.jpg (CuOTf)2C6H6 87% -
a

Isolated yield. Reaction conditions: 5 mol % catalyst, 1,4-dioxane 0.25 M, 110°C (entries 1, 2, 4 and 6); 10 mol % catalyst, PhMe 0.25 M, 100°C (entries 3, 5 and 7).

b

Inseparable mixture of 4 and 5 (1:1.5).