Table 1.
Systems used for producing vaccine candidates against protozoan parasitesa
| Organism | Disease | Candidateb | System |
|---|---|---|---|
| Plasmodium | Malaria | ABRA | Escherichia coli |
| MSP1 | Escherichia coli | ||
| AMA-1 | Escherichia coli | ||
| MSP1(42) | Escherichia coli | ||
| LSA-1 | Escherichia coli | ||
| RTSS/AS02A | Saccharomyce cerevisiae | ||
| Pfs25 | Pichia pastoris | ||
| Pvs25 | Saccharomyces cerevisiae | ||
| CSP | Saccharomyces cerevisiae | ||
| Toxoplasma | Toxoplasmosis | SAG1, -2 | Salmonella |
| OP2 | Plasmid DNA | ||
| Cryptosporidium | Cryptosporidiosis | P23, CP15 | Plasmid DNA |
| Theileria | East Coast fever | p67 | Baculovirus |
| Neospora | - | NcSAG1, -2 | Escherichia coli |
| NcGRA7, NcsHSP33 | Plasmid DNA | ||
| Babesia | Babebiosis | 12D3, 11C5 | Escherichia coli |
| Bd37 | Escherichia coli | ||
| Eimeria | - | EtMIC2 | Plasmid DNA |
a
This is not a comprehensive list. Not all of these proteins are mentioned in the main text.
b
ABRA, acidic basic repeat antigen; AMA, apical membrane antigen; EtMIC2, Eimeria tenella microneme protein 2; GRA, tachyzoite-dense granules; HSP, heat-shock protein; Pfs25, P. falciparum surface 25; Pvs25, P. vivax surface 25.