Fig. 1. STAT3^Mye−/− mice are more susceptible to liver inflammation, but resistant to necrosis/apoptosis induced by CCl₄.

Wild-type and STAT3^Mye−/− mice were injected with CCl₄, and then sacrificed at various time points. A. Serum ALT levels. B. H&E staining of liver tissues from the mice treated 24 h post CCl₄ injection. C. Necrotic area was quantified. D. Liver tissues were also stained with TUNEL to determine hepatocyte apoptosis, and the number of TUNEL⁺ hepatocytes was quantified. Values represent means±SD (n=4–10). *P<0.05, **P<0.01, ***P<0.001 in comparison with corresponding WT groups. WT: littermate wild-type control mice (LyzMCre⁻STAT3^flox/flox); STAT3^Mye−/−(LyzMCre⁺STAT3^flox/flox).