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. Author manuscript; available in PMC: 2011 Apr 30.
Published in final edited form as: Circ Res. 2010 Mar 11;106(8):1413–1424. doi: 10.1161/CIRCRESAHA.109.209312

Figure 2.

Figure 2

Effect of epinephrine plus caffeine or exercise on ventricular arrhythmia. A, Representative ECG recordings in WT and R2474S/+ KI mice. In all KI mice examined, bidirectional or polymorphic ventricular tachycardia (VT) was induced by epinephrine (2 mg/kg of body weight (BW) i.p.) and caffeine (120 mg/kg of body weight i.p.) (n=10) (top) or exercise with treadmill (n=6) (bottom). In WT mice, neither epinephrine plus caffeine (n=8) nor exercise (n=6) produced VT. B, Durations of VT and numbers of VT episodes observed during the 5 minutes period in WT and KI mice. VT was induced by only epinephrine (2 mg/kg of body weight i.p.) without caffeine. N: the number of mice examined.