Table 1.

Associations between novel birth weight loci and anthropometric traits at birth

Phenotype	Locus 3q25, nearest genes: CCNL1, LEKR1a				Locus 3q21, ADCY5b
	N	Effect	95%CI	P valuec	N	Effect	95%CI	P valuec
Birth weight Z-scored	37745	−0.086 SD	−0.100, −0.073	2×10−35	38214	−0.063 SD	−0.079, −0.047	7×10−15
Birth length Z-score	21512	−0.028 SD	−0.046, −0.010	0.002	21782	−0.044 SD	−0.066, −0.022	4×10−5
Birth head circumference Z-score	17349	−0.024 SD	−0.044, −0.004	0.017	17693	−0.025 SD	−0.048, −0.004	0.030
Ponderal indexe Z-score	21515	−0.094 SD	−0.113, −0.074	5×10−21	21785	−0.032 SD	−0.055, −0.009	0.006
Odds ratio for SGA <10th percentilef	30370	1.16	1.10, 1.23	1×10−7	30778	1.09	1.02, 1.16	0.009

Results are from inverse variance, fixed effects meta-analysis of all 19 study samples of European ancestry. The effect allele for each SNP is labelled on the positive strand according to HapMap. The effect is the beta coefficient (or odds ratio) for genotype, assuming an additive genetic model. If the index SNP was unavailable, this was substituted with a closely-correlated (HapMap r²>0.9) proxy (rs1482853 or rs900399 for rs900400; rs2877716 or rs6798189 for rs9883204). There was no evidence of between-study heterogeneity of effect size estimates (all P>0.18; I²<26%).

^aIndex SNP rs900400, effect allele C (40% frequency in HapMap CEU; range 32-47% in our European study samples).

^bIndex SNP rs9883204, effect allele C (73% frequency in HapMap CEU; range 71-83% in our European study samples).

^cThe P value for the birth weight meta-analysis includes the double-GC correction of the discovery meta-analysis.

^dExcluding the three studies that were unable to adjust for gestational age, the beta (s.e.m.), N and P values in the birth weight analysis were: −0.089(0.008), N=31510, P=7×10⁻³² (3q25); −0.068(0.009), N=31901, P=8×10⁻¹⁵ (3q21).

^ePonderal index = birth weight/length³.

^fSGA <5^th percentile, OR (P value): rs900400=1.11 (0.004); rs9883204=1.04 (0.41).