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. 2010 May 5;98(9):1847–1855. doi: 10.1016/j.bpj.2010.01.034

Figure 5.

Figure 5

Representation of dTC in the 5-HT3R binding site looking down from the top (i.e., facing the synapse) of the receptor. A model of the dTC/5-HT3R complex was obtained using MD calculations as described in the text. Residues used in the mapping (R92, N128, and E236) are shown in standard colors, and additional residues implicated in receptor/dTC interactions are shown in cyan ((+)-face) or green ((−)-face)). Note that R92 is close to the 2N, N128 is close to the 2′N, and E236 is close to the 12 –OH.