Table 1. Clinical phenotypes of Leber hereditary optic neuropathy patients.
| Patient ID | Age of onset (in years) | Sex | Neuro-imaging |
VA |
Fundus findings |
Fields |
||
|---|---|---|---|---|---|---|---|---|
| OD | OS | OD | OS | |||||
| LHON 1 |
22 |
M |
Normal |
CF3ft |
CF5ft |
diffuse disc pallor |
Not possible |
Not possible |
| LHON 2 |
25 |
M |
Normal |
20/80 |
20/50 |
diffuse disc pallor |
central scotoma |
central scotoma |
| LHON 3 |
27 |
M |
Normal |
CF5ft |
20/60 |
diffuse disc pallor |
Not possible |
central scotoma |
| LHON 4 |
24 |
M |
Normal |
HMCF |
LP only |
diffuse disc pallor |
Not possible |
Not possible |
| LHON 5 |
29 |
M |
Normal |
20/100 |
20/50 |
Severely diffuse disc pallor |
central scotoma |
central scotoma |
| LHON 6 |
26 |
M |
Normal |
20/200 |
20/100 |
diffuse disc pallor |
central scotoma |
central scotoma |
| LHON 7 |
28 |
M |
Normal |
CF5ft |
20/60 |
temporal disc pallor |
Not possible |
central scotoma |
| LHON 8 |
21 |
M |
Normal |
20/60 |
20/60 |
Severe diffuse disc pallor |
central scotoma |
central cecal scotoma |
| LHON 9 |
23 |
M |
Normal |
20/200 |
20/100 |
diffuse disc pallor |
central scotoma |
central scotoma |
| LHON 10 | 24 | M | Normal | CF1ft | 20/100 | diffuse disc pallor | Not possible | central scotoma |
Abbrevations: OD represents right eye; OS represents left eye; CF represents counting finger; ft represents distance in feet; HMCF represents hand motions close to face; LP represents light perception; VA represents visual acuity.