Table 2.

E _max and pEC₅₀ values measured in denuded bladders from mice 2–24 weeks after injection

Denuded bladder		2–3 weeks			8–9 weeks			20–24 weeks
		E max (mN)	E max (% KCl)	pEC50	E max (mN)	E max (% KCl)	pEC50	E max (mN)	E max (% KCl)	pEC50
Vehicle	WT	71.38 ± 6.87	268.10 ± 30.43	6.81 ± 0.14	48.17 ± 3.76	242.20 ± 8.82	6.83 ± 0.052	70.27 ± 6.15	215.60 ± 26.79	6.66 ± 0.14
	M2 KO	–	272.60 ± 26.26	6.39 ± 0.13	–	249.50 ± 15.35	6.86 ± 0.088	–	168.30 ± 6.51	6.53 ± 0.051
STZ	WT	63.12 ± 6.05	259.70 ± 11.89	6.73 ± 0.064	76.28 ± 4.94b	242.60 ± 8.93	6.73 ± 0.052	113.30 ± 7.12b	181.70 ± 12.84	6.72 ± 0.071
	M2 KO	–	238.50 ± 14.90	6.69 ± 0.087	–	208.60 ± 17.21	6.49 ± 0.11a	–	175.30 ± 3.08	6.40 ± 0.027

Data are means ± SE (number of animals)

^aStatistically significant difference from M₂ KO vehicle (P < 0.01)

^bSignificantly different from wild-type vehicle (P < 0.001)