Table 3.

E _max and pEC₅₀ values measured in intact bladders from mice 2–24 weeks after injection

Intact bladder		2–3 weeks			8–9 weeks			20–24 weeks
		E max (mN)	E max (% KCl)	pEC50	E max (mN)	E max (% KCl)	pEC50	E max (mN)	E max (% KCl)	pEC50
Vehicle	WT	51.50 ± 4.28	218.50 ± 18.04	6.87 ± 0.099	35.53 ± 3.96	197.20 ± 10.90	6.90 ± 0.080	68.64 ± 10.40	201.20 ± 26.81	6.62 ± 0.14
	M2 KO	–	242.20 ± 40.89	6.44 ± 0.22	–	227.20 ± 18.14	6.63 ± 0.11	–	168.80 ± 15.63	6.47 ± 0.096
STZ	WT	54.48 ± 8.48	269.70 ± 31.94	6.69 ± 0.16	53.63 ± 6.14a	248.60 ± 16.69a	6.91 ± 0.10	71.21 ± 6.17	161.40 ± 21.21	6.69 ± 0.14
	M2 KO	–	212.30 ± 19.14	6.80 ± 0.14	–	199.40 ± 14.93	6.70 ± 0.10	–	157.90 ± 11.02	6.36 ± 0.091

Data are means ± SE (number of animals)

^aStatistically significant difference from wild-type vehicle (P < 0.01)