Table 1.
Summary of iris phenotypes survey
| Strain name | Symbol | Gene | Background | Total no mice | Oldest (months) | Comments |
|---|---|---|---|---|---|---|
| albino | TyrC–2J | Tyrosinase | C57BL/6J | 12 | 7 | Total albinism |
| beige | Lystbg-J | Lysosomal trafficking regulator | C57BL/6J | 13 | 10 | Very dark iris and pigment dispersion |
| buff | Vps33abf | Vacuolar protein sorting 33A (yeast) | C57BL/6J | 7 | 5 | Mild transillumination increasing peripherally |
| chocolate | Rab38cht | Rab38, member of RAS oncogene family | C57BL/6J | 11 | 12 | Mild transillumination increasing peripherally |
| cocoa | Hps3coa | Hermansky-Pudlak syndrome 3 homolog | C57BL/6J | 12 | 7 | Uniformly hypopigmented |
| gunmetal | Rabggtagm | Rab geranylgeranyl transferase, a subunit | C57BL/6J | 7 | 5 | Wild-type |
| leaden | Mlphln | Melanophilin | C57BL/6J | 12 | 8 | Wild-type |
| light | Tyrp1B-lt | Tyrosinase related protein 1 | LT/SvEiJ | 46 | 22 | Pigment dispersion |
| nm2798 | DctSlt-lt3J | DOPAchrome tautomerase | C57BL16J | 18 | 19 | Pigment dispersion |
| pale ear | Hps1ep | Hermansky-Pudlak syndrome 1 homolog | C57BL/6J | 9 | 6 | Slightly dark iris |
| pallid | Pldnpa | Pallidin | C57BL/6J | 9 | 6.5 | Near total albinism |
| recessive yellow | Mc1re-J | Melanocortin 1 receptor | C57BL/6J | 7 | 5.5 | Wild-type |
| shaker 1 | Myo7aShl–8j | Myosin VIIa | C57BL/6J | 9 | 7 | Wild-type |
| silver | SiSi | Silver | a Tyrp1b Sisi/J | 15 | 24 | Wild-type, does not alter Tyrp1b |
| vitiligo | Mitfml-vit | Microphthalmia-associated transcription factor | C57BL/6J | 12 | 21.5 | Pigment dispersion |