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. Author manuscript; available in PMC: 2011 Apr 16.
Published in final edited form as: J Mol Biol. 2010 Feb 26;397(5):1276–1286. doi: 10.1016/j.jmb.2010.02.042

Figure 5.

Figure 5

Model for the initiation mechanism of SV40 DNA replication. LTag double hexamer assembled onto ori sequence in the presence of ADP (a) and in the presence of ATP (b). The bubbles indicate the distortion of the DNA structure. The distortion of the A/T- rich region requires the presence of ATP and the presence of the region 121–135 16, but not ATP hydrolysis 2; 7; 9. (c) The equilibrium between the straight and displaced conformations could be the mechanism for the ssDNA exit. (d) ATP hydrolysis powers the DNA unwinding.