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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Mater. 2009 Nov 8;8(12):993–999. doi: 10.1038/nmat2569

Figure 6. Genomic profiles of CP-Dox and free Dox treated tumor tissues.

Figure 6

a) Volcano plot of gene expression contrasting CP-Dox treated mice vs. Dox treated mice. Expression level is denoted by a square colored to reflect the P-value. The horizontal green line indicates the cutoff of P-value (P<0.00012), which corrects for multiple comparisons. The vertical green lines indicate the cutoff for significant fold change (>1.5 fold). In CP-Dox treated mice, 12 genes were significantly down-regulated, and 2 genes were up-regulated in contrast to Dox treated mice. b) A hierarchical clustering analysis was performed based on the expression pattern. The genes were linked together according to their expression patterns (dendrogram on left). Individual mice were also clustered (dendrogram on top). For all mice, the clustering results match their treatment: CP-Dox (red bar); Dox (blue bar); and PBS (green bar). The gene expression intensities were standardized between -2.0 (blue) and 2.0 (red). LOC*7155 is an abbreviation of an untitled gene LOC100047155.