. Author manuscript; available in PMC: 2010 May 3.

Published in final edited form as: Neurotox Res. 2009 May 28;16(2):148–159. doi: 10.1007/s12640-009-9064-7

Table 1.

Effects of rasagiline, selegiline, and 1-R-aminoindan on ethanol-induced MAO B activity and neuroprotection (percent control)

	MAO B inhibition		Inhibition of H₂O₂ generation (%)	Cell viability (MTT) (%)
	mRNA (%)	Catalytic activity (%)
Aminoindan (1 μM)	34	33	30	156
Rasagiline (0.25 nM)	58^*	61^*	43^#	181^#
Selegiline (0.25 nM)	44^#	45^#	30	140

Neuroprotective effect of MAO B inhibitors, rasagiline, and selegiline, as compared to 1-R-aminoindan (a major metabolite of rasagiline) on the inhibition of MAO B and the survival of a GAPDH-overexpressed cell line (U-118 MG) in ethanol-induced cell death (75 mM; 48 h for mRNA level or 72 h for catalytic activity, H₂O₂ generation and cell viability analysis). Controls were values obtained from Fig. 4, lane 7 (without drug treatment) which were taken as 100. Data represent the average of three independent experiments.

P < 0.02

P < 0.05 compared with 1-R-aminoindan (Aminoindan)